A synergistic blend of polyphenols and amino acids, including leucine, to support normal insulin regulation in horses showing symptoms of equine metabolic syndrome (EMS). The propriety blend of ingredients in InsulinWise are research-proven to support lower insulin levels and increased adiponectin concentrations in EMS horses. Maintaining normal levels of these hormones and decreasing insulin dysregulation can provide a clinical benefit by reducing the risk of laminitis.