D-cloprostenol is a synthetic analogue of the prostaglandin F2a. In cows, 2 mL/cow intramuscular injection is labelled for synchronisation or induction of oestrus, induction of parturition after day 270 of gestation, treatment of ovarian dysfunction (persistent corpus luteum, luteal cyst), treatment of clinical endometritis with the presence of a functional corpus luteum and pyometra, induction of abortion up to day 150 of gestation, expulsion of mummified foetuses, delayed uterine involution, and therapy for the treatment of ovarian cysts (9-14 days after initial administration of GnRH or analogue). In sows, 1 mL/sow intramuscular injection is labelled for induction of parturition after day 114 of gestation. In mares, 1 mL/mare intramuscular injection is labelled for induction of luteolysis in mares with a functional corpus luteum.